A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

Part of paid clinical trials in Los Angeles, California.

Sponsor
Crinetics Pharmaceuticals Inc.
Study ID
NCT07144163
Phase
PHASE3
Status
Recruiting
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Conditions

  • Classic Congenital Adrenal Hyperplasia
  • Congenital Adrenal Hyperplasia

Eligibility Criteria

Sex
ALL
Age
18 Years - 74 Years
Healthy Volunteers
Not accepted

Interventions

  • Atumelnant — DRUG
    Atumelnant, tablets, once daily by mouth
  • Placebo — DRUG
    Placebo, tablets, once daily by mouth

Study Details

The purpose of this study is to evaluate the efficacy, safety, PK, and PD of atumelnant in adults with classic CAH due to 21-OHD.

Key Dates

Start date
Dec 11, 2025
Status verified
May 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment
    Atumelnant tablet, administered orally, once daily for 32 weeks.
  • Placebo Comparator: Placebo
    Matching placebo, administered orally, once daily for 32 weeks.

Primary Outcome Measure

Proportion of participants with morning post-GC A4 ≤ ULN who are on physiologic GC replacement. [ Time Frame: Week 32 ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
Crinetics Study SiteLos AngelesCalifornia90027-
Crinetics Study SiteAtlantaGeorgia30322-
Crinetics Study SiteChicagoIllinois60611-
Crinetics Study SiteAnn ArborMichigan48109-
Crinetics Study SiteMinneapolisMinnesota55417-
Crinetics Study SiteRochesterMinnesota55905-
Crinetics Study SitePittsburghPennsylvania15213-
Crinetics Study SiteDallasTexas75390-
Crinetics Study SiteMilwaukeeWisconsin53226-

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Crinetics Study Site· Los Angeles, CACrinetics Study Site· Atlanta, GACrinetics Study Site· Chicago, ILCrinetics Study Site· Ann Arbor, MICrinetics Study Site· Minneapolis, MNCrinetics Study Site· Rochester, MN

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