Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying

Part of paid clinical trials in Detroit, Michigan.

Sponsor
Wael Saasouh, MD
Study ID
NCT07140289
Status
Enrolling By Invitation

Conditions

  • Gastric Emptying
  • Glucagon-Like Peptide-1 Receptor Agonists
  • Intermittent Fasting
  • Intraoperative Complication Due to Anesthesia
  • Respiratory Aspiration of Gastric Contents

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • Ultrasound of gastric contents — DIAGNOSTIC_TEST
    An ultrasound examination of the abdomen to observe and measure gastric contents

Study Details

This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients. GLP-1 receptor agonists are mainly used for the treatment and mitigation of obesity and metabolic syndromes. One of their mechanisms of action is by delaying gastric emptying, hence increasing satiety. However, patients need to abstain from eating for a set amount of time before surgery to reduce the risk of aspiration. Hence patients who use GLP-1 receptor agonists may need more time to abstain eating (nil-per-os). In this study we aim to assess how much time is sufficient before surgery in these specific population of patients.

Key Dates

Start date
Sep 1, 2025
Status verified
Aug 2025
Primary completion
Jun 1, 2027
Completion
Jun 1, 2028

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Study group
    Adult patients who are receiving a Glucagon-like peptide-1 Receptor Agonist and scheduled for any elective surgery or procedure under anesthesia.

Primary Outcome Measure

Gastric cross-sectional area [ Time Frame: Preoperatively on the day of surgery (between admission to preoperative testing and start of surgical procedure). ]

Locations (1)

FacilityCityStateZIPSite coordinators
Detroit Medical CenterDetroitMichigan482001-

Find similar trials in Detroit, MI

By research site
Detroit Medical Center· Detroit, MI

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