Vaped Phenanthrene

Conditions

• Former Smoker
• Non-Smoker

Eligibility Criteria

Sex

ALL

Age

21 Years - N/A

Healthy Volunteers

Accepted

Interventions

• D10-phenanthrene — OTHER
  All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].

Study Details

Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future. This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.

Key Dates

Start date

Jul 1, 2026

Status verified

Jun 2026

Primary completion

Sep 1, 2027

Completion

Jun 30, 2028

Study Design

Enrollment

100 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Other: D10-phenanthrene
  All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].

Primary Outcome Measure

Urinary Ratio of D10PheT/D9PhOH [ Time Frame: 24 hours after vaping phenanthrene ]

Central Contacts

• Nya Jock
  612-624-4568
  [email protected]

Locations (1)

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