The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

Part of paid clinical trials in Cleveland, Florida.

Sponsor
The Cleveland Clinic
Study ID
NCT07127354
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

  • Bowel Preparation for Colonoscopy
  • GLP - 1

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Continue GLP/GIP — DRUG
    Continue GLP-1 or GIP-based therapy as prescribed prior to the procedure.

Study Details

The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are: * Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation? * Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication? * Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?

Key Dates

Start date
Aug 1, 2025
Status verified
Nov 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
132 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Continue GLP/GIP medication
    Patient maintains dose, frequency, duration of medication prior to colonoscopy.
  • No Intervention: Hold medication
    Withholds prior dose of GLP-1 or GIP therapy per ASA guidance recommendations

Primary Outcome Measure

Rate of inadequate bowel preparation [ Time Frame: During Surgery ]

Locations (3)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandFlorida44195
Samita Garg, M.D.
[email protected]
216-444-7000
Samita Garg, M.D. (PRINCIPAL_INVESTIGATOR)
Cleveland ClinicClevelandFlorida44195
Samita Garg, MD
[email protected]
216-444-2386
Samita Garg, MD (PRINCIPAL_INVESTIGATOR)
Cleveland Clinic WestonWestonFlorida33331
Tilak Shah, M.D.
[email protected]
877.463.2010
Akram Ahmad, M.D.
[email protected]
Tilak Shah, M.D. (PRINCIPAL_INVESTIGATOR)

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