Probenecid Administration for Alcohol Craving and Consumption

Part of paid clinical trials in Providence, Rhode Island.

Sponsor
Brown University
Study ID
NCT07118618
Phase
PHASE2
Status
Recruiting
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Conditions

  • Alcohol Consumption
  • Alcohol Use Disorder (AUD)
  • Craving

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Probenecid Oral Tablet — DRUG
    2gr daily
  • Placebo Oral Tablet — DRUG
    Inactive compound

Study Details

This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.

Key Dates

Start date
Mar 14, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2030
Completion
Dec 31, 2030

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Study drug
    Probenecid 2gr oral
  • Placebo Comparator: Placebo
    Placebo inactive

Primary Outcome Measure

Acute Alcohol Craving [ Time Frame: 5- week ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brown UniversityProvidenceRhode Island02903
Brian Gully, MA
[email protected]

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