Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States

Part of paid clinical trials in Downey, California.

Sponsor
University of Southern California
Study ID
NCT07110688
Status
Recruiting
Apply to this trial

Conditions

  • No Condition
  • Study Mental State in Healthy Populations and Drug-resistant Epilepsy Patients With Existing iEEG

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Virtual human social interaction — BEHAVIORAL
    The participants will perform a social interaction with the virtual human agent platform to assess mental states.
  • Cold pressor test — BEHAVIORAL
    Healthy participants will immerse one hand in cold water for less than 3 minutes, while physiological data will be collected by the new wearable sensor from the other hand.

Study Details

In this program, the investigators will develop novel multimodal neural-behavioral-physiological monitoring tools (software and hardware), and machine learning models for mental states within social processes and beyond. The tools consist of a multimodal skin-like wearable sensor for physiological and biochemical sensing; a conversational virtual human platform to evoke naturalistic social processes; audiovisual affect recognition software; synchronization tools; and machine learning methods to model the multimodal data. The investigators will demonstrate the tools in healthy subjects without neural recordings and in patients with drug-resistant epilepsy who already have intracranial EEG (iEEG) electrodes implanted based on clinical criteria for standard monitoring to localize seizures, which is unrelated to our study.

Key Dates

Start date
Aug 1, 2024
Status verified
Jul 2025
Primary completion
Nov 30, 2028
Completion
Nov 30, 2028

Study Design

Enrollment
90 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Behavioral tasks to assess mental states

Primary Outcome Measure

Positive and Negative Affect Schedule (PANAS) [ Time Frame: 7-10 days ]

Locations (2)

FacilityCityStateZIPSite coordinators
Rancho Los Amigos National Rehabilitation CenterDowneyCalifornia90242
Charles Liu, MD, PhD
[email protected]
323-226-7421
University of Southern CaliforniaLos AngelesCalifornia90007
Maryam M Shanechi, PhD
[email protected]
213-740-1377
HyeongChan Jo, PhD
[email protected]
Maryam M Shanechi, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Rancho Los Amigos National Rehabilitation Center· Downey, CAUniversity of Southern California· Los Angeles, CA

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