SLV-324 Treatment of Metastatic Solid Tumors

Part of paid clinical trials in Newport Beach, California.

Sponsor
Solve Therapeutics
Study ID
NCT07108114
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Metastatic Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • SLV-324 intravenous (IV infusion) — DRUG
    SLV-324 will be administered as an IV infusion

Study Details

This is a Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and efficacy of SLV-324 across a range of dose levels when administered to subjects with metastatic solid tumors.

Key Dates

Start date
Aug 25, 2025
Status verified
Feb 2026
Primary completion
May 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
70 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: SLV-324 intravenous (IV infusion)
    SLV-324 will be administered at different dose levels in dose-escalation cohorts and at the RDR in dose expansion cohorts

Primary Outcome Measure

MTD or RDR [ Time Frame: Through the duration of treatment, up to approximately 18 months ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Hoag Memorial Hospital PresbyterianNewport BeachCalifornia92663
Cindy Do, BSN, RN
[email protected]
949-764-4624
Washington UniversitySt LouisMissouri63110
Sara Mitchum
[email protected]
314-273-8602
University Hospitals Cleveland Medical CenterClevelandOhio44106
Megan Boland
[email protected]
216-286-3379
Kelsi Wood
[email protected]
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111
Dajah White-Dumpson
[email protected]
215-728-4798
Shannon Fabrie
[email protected]
Mays Cancer Center; University of Texas Health San AntonioHoustonTexas78229
Daruka Mahadevan, MD
[email protected]
210-450-1000
Daruka Mahadevan, MD (PRINCIPAL_INVESTIGATOR)
MD Anderson Cancer CenterHoustonTexas77030
Rabia Khan
[email protected]
713-563-4667
University of Washington / Fred Hutchinson Cancer CenterSeattleWashington98109
University of Washington/Fred Hutchinson Cancer Center Phase 1 Clinical Trials
[email protected]
206-606-7551

Find similar trials in Newport Beach, CA

By research site
Hoag Memorial Hospital Presbyterian· Newport Beach, CAWashington University· St Louis, MOUniversity Hospitals Cleveland Medical Center· Cleveland, OHFox Chase Cancer Center· Philadelphia, PAMays Cancer Center; University of Texas Health San Antonio· Houston, TXMD Anderson Cancer Center· Houston, TX

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