Visual Plasticity Following Brain Lesions

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
Georgetown University
Study ID
NCT07105358
Status
Recruiting
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Conditions

  • Brain Tumor
  • Cortical Blindness
  • Hemianopia
  • Quadrantanopia
  • Stroke
  • Traumatic Brain Injury
  • Visual Field Defect
  • Visual Field Defect, Peripheral

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • transcranial random noise stimulation (tRNS) — DEVICE
    Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: 1 mA current intensity, with a frequency range of 101-640 Hz.
  • Sham Stimulation — DEVICE
    Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: Ramp up stimulation at 1mA with a frequency range of 101-640Hz for the first 30 seconds followed by no current for the remainder of the duration.
  • Perceptual learning-based training — BEHAVIORAL
    A motion discrimination task, judging the global direction of moving dot stimuli with two different coherence levels.

Study Details

The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.

Key Dates

Start date
Jul 17, 2025
Status verified
Jul 2025
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: tRNS with perceptual learning-based training
    Each 2-day session consists of up to three 18-minute transcranial random noise stimulation (tRNS) paired with perceptual learning-based training.
  • Sham Comparator: Sham with perceptual learning-based training
    Each 2-day session consists of up to three 18-minute sham stimulation paired with perceptual learning-based training.

Primary Outcome Measure

Change in Motion Discrimination Performance [ Time Frame: Study visit 1 to 2 (within a week), and study visit 3 to 4 (within a week) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Georgetown University Medical CenterWashington D.C.District of Columbia20057
Visual Perception and Plasticity Lab
[email protected]
202-784-9949
Tina Liu, PhD (PRINCIPAL_INVESTIGATOR)

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