Strength Training Response of Muscle in GLP-1 Users

Conditions

• Muscle Mass

Eligibility Criteria

Sex

ALL

Age

50 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Strength Training — BEHAVIORAL
  Participants taking a GLP-1 will undergo a 14-week strength training regimen to determine changes in muscle mass. They will perform a series of resistance training exercises supervised by a personal trainer on 3 days per week.
• Wait first, then strength training — OTHER
  Participants will be waitlisted and receive the 14-week strength training intervention at the end of the waitlist period. During the waitlist period, participants will get no intervention and then be offered the strength training intervention after the first 14 weeks.

Study Details

GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.

Key Dates

Start date

Oct 8, 2025

Status verified

Jan 2026

Primary completion

Dec 31, 2026

Completion

May 31, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: Strenth Training
  Participants will undergo strength training 3 times per week for 14 weeks.
• Other: Waitlisted control
  Participants will have no strength training intervention for 14 weeks. Participants will be offered the same 14-week strength training program after the initial 14 weeks.

Primary Outcome Measure

Muscle mass by d3-creatine dilution [ Time Frame: Water containing creatine isotope consumed in lab; Urine sample collection on Day 0 and Day 3 at baseline and 14 weeks. ]

Central Contacts

• Kevin Davy
  540-231-3487
  [email protected]
• Elaina Marinik
  540-231-0923
  [email protected]

Locations (1)

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