PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department

Conditions

• Supraventricular Tachycardia (SVT)

Eligibility Criteria

Sex

ALL

Age

18 Years - 100 Years

Healthy Volunteers

Not accepted

Interventions

• IV adenosine — DRUG
  Patients will not be randomized to intervention but will be categorized based on the exposure of IV adenosine for treatment of SVT received prior to study enrollment
• IV diltiazem — DRUG
  Patients will not be randomized to intervention but will be categorized based on the exposure of IV diltiazem for treatment of SVT received prior to study enrollment

Study Details

Supraventricular tachycardia (SVT) is a dysrhythmia characterized rapid heart rate, typically with rapid onset. SVT accounts for over 50,000 emergency department visits per year. Of patients with regular, narrow-complex SVT, the mainstay of therapy includes adenosine and diltiazem. Adenosine is recommend by American and European guidelines as first-line therapy, however adenosine carries unique side effects that are potentially distressing to patients, including: "feeling of impending death or doom", flushing, anxiety, shortness of breath, and chest discomfort. Diltiazem does not carry this side effect profile, but has typically been reserved as second-line treatment due to side effects of low blood pressure associated with this class of medications. Diltiazem and adenosine have not been well studied head-to-head to compare safety and efficacy of their treatment for SVT. The purpose of this study is to evaluate safety and efficacy of adenosine and diltiazem for SVT in the ED (as completed through chart review of specific patient-level outcomes) and capture patient and clinician perspectives of medication satisfaction (through administration of questionnaires).

Key Dates

Start date

Apr 4, 2025

Status verified

May 2026

Primary completion

Jun 30, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

20 participants (estimated)

Arms

• Arm: Adenosine
• Arm: Diltiazem

Primary Outcome Measure

Patient satisfaction with SVT treatment [ Time Frame: Primary outcome will be assessed during ED visit ]

Central Contacts

• Anne Zepeski, PharmD
  651-207-9357
  [email protected]

Locations (1)

Find similar trials in Iowa City, IA

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• Adenosine vs Diltiazem for Treatment of SVT in the ED
  PHASE4 · Recruiting · Anne E. Zepeski · Iowa City, Iowa