Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy

Part of paid clinical trials in Jacksonville, Florida.

Sponsor
Mayo Clinic
Study ID
NCT07086183
Status
Not Yet Recruiting

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Conditions

  • Aneurysm Cerebral

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Observation — OTHER
    Observation of intraoperative and postoperative outcomes

Study Details

This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm. Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots? To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery. The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.

Key Dates

Start date
Dec 1, 2026
Status verified
Jan 2026
Primary completion
Dec 1, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Chronic aspirin
    Patients on chronic aspirin
  • Arm: No aspirin
    Patients who are not on aspirin

Primary Outcome Measure

Postoperative Hemorrhage Rate [ Time Frame: 48 hours postoperatively ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic FloridaJacksonvilleFlorida32224
Shaun Gruenbaum, MD, PhD
[email protected]
904-953-2000
Shaun Gruenbaum, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Mayo Clinic Florida· Jacksonville, FL

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