TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

Part of paid clinical trials in Palo Alto, California.

Sponsor
Treeline Biosciences, Inc.
Study ID
NCT07082803
Phase
PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • TLN-121 — DRUG
    Specified dose on specified days.
  • TLN-254 — DRUG
    Specified dose on specified days.
  • TLN-121 — DRUG
    Specified dose on specified days.

Study Details

The primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of TLN-121 as a single agent and in combination with other anti-lymphoma therapies in patients with relapsed or refractory Non-Hodgkin Lymphomas

Key Dates

Start date
Jun 23, 2025
Status verified
Mar 2026
Primary completion
Sep 30, 2030
Completion
Nov 30, 2030

Study Design

Enrollment
180 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Single Agent
  • Experimental: Combination Treatment

Primary Outcome Measure

Number of participants experiencing adverse events (AEs) that meet protocol-defined dose-limiting toxicity (DLT) criteria following administration of TLN-121 alone or in combination with TLN-254. [ Time Frame: Up to 2 years ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
Stanford Medicine Cancer CenterPalo AltoCalifornia94304
Yeung
[email protected]
650-736-1908
The START Center for Cancer Care - MidwestGrand RapidsMichigan49546
Andrew Sochacki
[email protected]
616-389-1800
Washington University School of MedicineSt LouisMissouri63108
Amalia Dubois
[email protected]
314-273-1486
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Steven Horwitz
[email protected]
SCRI Oncology PartnersNashvilleTennessee37203
Principal Investigator
[email protected]
615-339-0516
The University of Texas MD Anderson Cancer CenterHoustonTexas77030
Dai Chihara, Dr.
[email protected]
713-792-2860

Find similar trials in Palo Alto, CA

By research site
Stanford Medicine Cancer Center· Palo Alto, CAThe START Center for Cancer Care - Midwest· Grand Rapids, MIWashington University School of Medicine· St Louis, MOMemorial Sloan Kettering Cancer Center· New York, NYSCRI Oncology Partners· Nashville, TNThe University of Texas MD Anderson Cancer Center· Houston, TX

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