Implant Phenotype Modification Via GBR and ADM

Conditions

• Horizontal Ridge Deficiency

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Dental implant placement — PROCEDURE
  Participants will have a dental implant placed at a toothless site
• Guided bone regeneration with collagen membrane — PROCEDURE
  Participants will receive guided bone regeneration at a toothless site with bone substitute and a collagen membrane.
• Guided bone regeneration with acellular dermal matrix. — PROCEDURE
  Participants will receive guided bone regeneration at a toothless site with bone substitute and an acellular dermal matrix.

Study Details

Single implant sites with bone loss can often be managed by bone grafting alone. The purpose of this study is to determine whether putting a soft tissue graft substitute over the bone graft will provide an increased benefit for improving the health, appearance, and stability of the bone and gums surrounding the implant.

Key Dates

Start date

Jun 1, 2025

Status verified

Jun 2025

Primary completion

Jul 1, 2026

Completion

Sep 1, 2026

Study Design

Enrollment

40 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Guided bone regeneration
  Guided bone regeneration with collagen membrane
• Experimental: Guided bone regeneration with Phenotype modification.
  Guided bone regeneration with an allogenic dermal matrix

Primary Outcome Measure

Horizontal linear change of the buccal bone [ Time Frame: 6 months ]

Central Contacts

• David Dunbar, DDS
  734-763-3346
  [email protected]
• Alice Ou, RDH, MS
  734-763-3346
  [email protected]

Locations (1)

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