A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Alexion Pharmaceuticals, Inc.
Study ID
NCT07081646
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Amyloidosis
  • Light Chain Amyloidosis
  • Refractory AL Amyloidosis
  • Relapsed AL Amyloidosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • AZD0120 — DRUG
    Participants will receive AZD0120 via intravenous (IV) infusion.

Study Details

Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis.

Key Dates

Start date
Aug 18, 2025
Status verified
Mar 2026
Primary completion
Aug 15, 2029
Completion
Feb 14, 2031

Study Design

Enrollment
91 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: AZD0120
    Participants will receive weight-based dose of AZD0120.

Primary Outcome Measure

Phase 1b: Number of Participants With incidence and severity of Treatment-emergent Adverse Events [ Time Frame: Through study completion, a minimum of 6 months ]

Central Contacts

Locations (12)

FacilityCityStateZIPSite coordinators
Research SitePhoenixArizona85028-
Research SiteSan FranciscoCalifornia94143-
Research SiteTampaFlorida33612-
Research SiteBostonMassachusetts02215-
Research SiteDetroitMichigan48201-
Research SiteRochesterMinnesota55905-
Research SiteSt LouisMissouri63110-
Research SiteNew YorkNew York10016-
Research SiteNew YorkNew York10032-
Research SiteNew YorkNew York10065-
Research SiteClevelandOhio44195-
Research SiteNashvilleTennessee37232-

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