Replacing Bone Marrow Diagnostics With Peripheral Blood Analysis in Cytopenia Patients

Part of paid clinical trials in San Diego, California.

Sponsor
Weizmann Institute of Science
Study ID
NCT07081087
Status
Recruiting
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Conditions

  • Cytopenia
  • MDS

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • PERIBLOOD-MDS — DIAGNOSTIC_TEST
    In the study, peripheral blood will be taken from all patients, shipped and analyzed at the Weizmann Institute of Science to produce a report based on our technology. The report will contain data on the diagnosis, blast counts and karyotype. This information will be compared with the results from the bone marrow scan, taken separately to each patient, to validate the accuracy of our technology

Study Details

This observational, multi-center study aims to collect data in order to develop a novel, minimally invasive diagnostic tool for MDS based on peripheral blood profiling of circulating hematopoietic stem and progenitor cells (cHSPCs) using single-cell RNA sequencing and DNA sequencing.

Key Dates

Start date
Jun 1, 2025
Status verified
Sep 2025
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
1,500 participants (estimated)

Arms

  • Arm: PERIBLOOD-MDS
    No intervention is given

Primary Outcome Measure

To develop PERIBLOOD-MDS diagnostic test of PB cHPCs for the diagnosis of MDS [ Time Frame: Three months following the peripheral blood sample ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of California San DiegoSan DiegoCalifornia92093
Tan Tuyet
Rafael Bejar (PRINCIPAL_INVESTIGATOR)
University of MiamiMiamiFlorida33146
Helen Kattoura, Dr.
305-243-6438
Stephen Nimer (PRINCIPAL_INVESTIGATOR)

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