The Role of mGluR5 in CBT-I

Part of paid clinical trials in Stony Brook, New York.

Sponsor
Stony Brook University
Study ID
NCT07076342
Phase
PHASE4
Status
Recruiting
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Conditions

  • Major Depressive Disorder (MDD)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Behavioral Therapy for Insomnia — BEHAVIORAL
    Cognitive Behavioral Therapy for Insomnia (CBT-I) will be delivered through an online program, Sleep Healthy Using The Internet Sleep Healthy Using The Internet (SHUTi)
  • PET Scan with [11C]ABP688 — DRUG
    Prior to and after completing the CBT-I protocol, participants will undergo a PET scan using tracer \[11C\]ABP688) to quantify hippocampal mGluR5 density.

Study Details

This is mechanistic clinical trial that evaluates the role of one of the glutamate receptors (mGluR5) in cognitive behavioral therapy for insomnia (CBT-I) as a common pathway in improving sleep and depression.

Key Dates

Start date
Aug 1, 2025
Status verified
Aug 2025
Primary completion
Mar 31, 2030
Completion
Mar 31, 2030

Study Design

Enrollment
42 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Cognitive Behavioral Therapy for Insomnia Treatment Arm
    Cognitive Behavioral Therapy for Insomnia (CBT-I) will be delivered through an online program, Sleep Healthy Using The Internet (SHUTi).

Primary Outcome Measure

Change in Sleep Latency from Baseline to 8 Weeks [ Time Frame: Baseline and 8 Weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stony Brook University: Dept of PsychiatryStony BrookNew York11794
Christine DeLorenzo, PhD
[email protected]
(631) 638-1523

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By research site
Stony Brook University: Dept of Psychiatry· Stony Brook, NY

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