Rebalancing the Fat Content of the Heart and Muscles

Sponsor
University of Aberdeen
Study ID
NCT07065383
Status
Recruiting
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Conditions

  • Diabetes Mellitus Type 2

Eligibility Criteria

Sex
ALL
Age
20 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

Traditional diabetes therapies focus on improving blood sugar control. However, many studies show that this may not be enough. New treatments focusing on weight loss have heralded better results. One of these treatments is Semaglutide and the investigators wish to examine its effects further in this study. The investigators propose to investigate what happens to the fat inside the heart and the leg muscles.

Key Dates

Start date
Aug 1, 2025
Status verified
Jul 2025
Primary completion
Jul 31, 2028
Completion
Jul 31, 2028

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Semaglutide administration plus dietary counselling and physical activity encouragement
    Semaglutide administration plus dietary counselling and physical activity encouragement
  • Active Comparator: Semaglutide and supervised training program
    Semaglutide administration plus a personalised and supervised program of resistance and endurance training

Primary Outcome Measure

1H-magnetic resonance spectroscopy [ Time Frame: From enrollment to the end of treatment at the end of 12 weeks ]

Central Contacts

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