A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

Part of paid clinical trials in Farmington, Connecticut.

Sponsor
UConn Health
Study ID
NCT07062237
Status
Recruiting
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Conditions

  • Infertility
  • Male Factor Infertility

Eligibility Criteria

Sex
ALL
Age
18 Years - 42 Years
Healthy Volunteers
Not accepted

Interventions

  • Ultrashort abstinence — OTHER
    Ultrashort abstinence: producing a sperm sample after 1 hour of abstinence.
  • Standard abstinence — OTHER
    Standard abstinence: producing a sperm sample after 2-5 days of abstinence.

Study Details

This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.

Key Dates

Start date
Jul 27, 2025
Status verified
Jun 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
187 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Ultrashort abstinence
    Half of participants eggs will be exposed to sperm produced after ultrashort abstinence (1 hour of abstinence).
  • Active Comparator: Standard abstinence
    Half of participants eggs will be exposed to sperm produced after standard abstinence (2-5 days of abstinence).

Primary Outcome Measure

Euploidy rate per oocyte [ Time Frame: Within 2-4 weeks of IVF cycle ]

Locations (1)

FacilityCityStateZIPSite coordinators
The Center for Advanced Reproductive Services, P.C.FarmingtonConnecticut06032
Lawrence Engmann, M.D., M.R.C.O.G
[email protected]
(844) 467 3483
Lawrence Engmann, MD; MRCOG (PRINCIPAL_INVESTIGATOR)

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By research site
The Center for Advanced Reproductive Services, P.C.· Farmington, CT

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