Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT07053033
Phase
PHASE2
Status
Recruiting
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Conditions

  • Brain Metastases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Surgery — PROCEDURE
    Participants will initially undergo craniotomy and surgical resection of lesions or LITT
  • LITT — PROCEDURE
    Participants will undergo 4-core stereotactic biopsy and LITT by experienced neurosurgeons with specific expertise.

Study Details

standard paradigm for management of patients who present with concern for recurrence of brain metastases following initial stereotactic radiosurgery (SRS).

Key Dates

Start date
Jan 1, 2026
Status verified
Mar 2026
Primary completion
Dec 30, 2026
Completion
Dec 30, 2028

Study Design

Enrollment
155 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Eligible for surgery or LITT-Surveillance
    Patients will be randomized in a 1:1 manner to close surveillance versus SRS2.
  • Experimental: Eligible for surgery or LITT-SRS2
    Patients will be randomized in a 1:1 manner to close surveillance versus SRS2.
  • Experimental: Ineligible for surgery or LITT-SRS2
    Patients will be randomized in a 1:1 manner to close surveillance versus SRS2.

Primary Outcome Measure

Safety and Adverse Events (AEs) [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas M. D. Anderson Cancer CenterHoustonTexas77030
Subha Perni, MD
[email protected]
713-563-2543
Subha Perni, MD (PRINCIPAL_INVESTIGATOR)

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By research site
The University of Texas M. D. Anderson Cancer Center· Houston, TX

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