Testing the Effect of Sulforaphane, a Compound Naturally Found in Cruciferous Vegetables, on Preventing Melanoma in Patients With a Prior History of Melanoma

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Eastern Cooperative Oncology Group
Study ID
NCT07040280
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Sulforaphane (broccoli sprout extract) — DRUG
    Sulforaphane - Three tablets of Avmacol® Extra Strength \[Nutramax\] by mouth, once daily, for 12 months.
  • Placebo — DRUG
    Three tablets by mouth, once daily, for 12 months
  • Derma-AI — DEVICE
    Photographs of lesions as part of the clinical exam at baseline, three (3) months, and twelve (12) months. These photographs will be submitted for assessment by a software called Derma-AI, which tracks moles over time for changes in size, number, and appearance

Study Details

The goal of this clinical trial is to compare the safety and effects of sulforaphane with the safety and effects of placebo on people's risk of developing melanoma. The main question it aims to answer is: Will giving sulforaphane (a broccoli sprout extract) have a meaningful effect on how your atypical moles change over time? If there is an effect, will this lower your risk of developing melanoma? Participants will: Take sulforaphane or a placebo for 12 months Visit the clinic once every 3 months for checkups and tests You will keep a calendar which will help you keep track of when you take your tablets

Key Dates

Start date
Oct 31, 2025
Status verified
Jun 2025
Primary completion
Feb 1, 2029
Completion
Aug 1, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: A
    Three tablets of Avmacol® Extra Strength \[Nutramax\] by mouth, once daily, for 12 months
  • Placebo Comparator: B
    Placebo - Three tablets by mouth, once daily, for 12 months

Primary Outcome Measure

Changes in the total area of nevi after 12 months of treatment from the baseline between sulforaphane and placebo arms [ Time Frame: 12 months of treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UPMC Hillman Cancer CenterPittsburghPennsylvania15213
John Kirkwood, MD
[email protected]
412-623-7707

Find similar trials in Pittsburgh, PA

By condition
Melanoma
By specialty
OncologySkin cancerDermatology
By research site
UPMC Hillman Cancer Center· Pittsburgh, PA

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