Investigation of Lymph Node Biology in Kidney Cancer

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT07038733
Status
Recruiting
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Conditions

  • Renal Cell Carcinoma (RCC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Peripheral Blood Sample for Immune Analysis — PROCEDURE
    A peripheral blood sample will be collected at the time of surgery.
  • Tumor Sample for Analysis — PROCEDURE
    Extra tumor which is left over following clinical diagnoses will be collected.
  • Adjacent non-malignant kidney for analysis — PROCEDURE
    Extra normal tissue which is left over following clinical diagnoses will be collected.
  • Draining lymph node(s) for analysis — PROCEDURE
    Draining lymph nodes which have been identified by the surgeon visually, potentially using a tracer (injection of up to 5mg of ICG into the peritumor kidney) will be collected.
  • Regional non-draining lymph node(s) for analysis — PROCEDURE
    Regional lymph nodes which have been deemed as non-draining by the surgeon will be collected.

Study Details

The purpose of this pilot study is to investigate the phenotype, anti-tumor effector functions, and TCR repertoire of T cells isolated from patient tumor draining lymph nodes (TDLNs) to understand T cell priming and trafficking patterns in Renal Cell Carcinoma (RCC). Data and biospecimen collected will be used for current and future research projects involving the study of kidney cancer biology and related medical conditions. We will use this valuable resource to ask clinically relevant translational questions that pertain to biomarker discovery/validation, identification of novel therapeutic targets, and to better understand the genetic and biological basis of the various kidney cancers.

Key Dates

Start date
Jan 30, 2026
Status verified
Jan 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Specimen collection
    This single arm study will assess adult patients with either a known or suspected kidney cancer referred to Yale Genitourinary Oncology providers in the Yale Urology, Medical Oncology, Radiation Oncology, or Nephrology Departments. Specimens collected will include peripheral blood sample for immune analysis, tumor sample for analysis, adjacent non-malignant kidney for analysis, draining lymph nodes for analysis and finally, regional non-draining lymph nodes for analysis.

Primary Outcome Measure

Molecular Profiling of Tumor and Draining Lymph Node Tissues in Kidney Cancer Patients [ Time Frame: 24 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale UniversityNew HavenConnecticut06510
Jialing Zhang
[email protected]
David Braun (PRINCIPAL_INVESTIGATOR)

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Yale University· New Haven, CT

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