Transcranial Magnetic Stimulation for Chronic Scrotal Content Pain

Part of paid clinical trials in Charleston, South Carolina.

Sponsor: Medical University of South Carolina
Study ID: NCT07035119
Phase: PHASE1/PHASE2
Status: Not Yet Recruiting

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Conditions

Scrotal Pain

Eligibility Criteria

Sex: MALE
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Transcranial magnetic stimulation — OTHER
Resting motor threshold will be established by first finding the area of the motor cortex associated with visible twitch of the right abductor pollicis brevis (APB). Parameter Estimation by Sequential Testing (PEST) will be conducted to quantify resting motor threshold using visible APB twitch. The left dorsolateral prefrontal cortex (DLPFC) will be located using the Beam F3 method and marked with a felt-tipped marker on the scalp. TMS will be delivered over left DLPFC at 110% of resting motor threshold at 10Hz (5-seconds-on; 10-seconds-off) for 15 minutes per session (3000 pulses), 3 sessions each day (30-minute rest in-between sessions), for 3 days (within 5 consecutive days; a total of 27,000 pulses).

Study Details

The purpose of this study is to perform an open label feasibility trial of TMS for the treatment of chronic scrotal content pain.

Key Dates

Start date: Jun 30, 2026
Status verified: Jun 2026
Primary completion: Apr 1, 2030
Completion: Apr 1, 2030

Study Design

Enrollment: 50 participants (estimated)
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Arms

Experimental: Open label
Open label study. Participants will be screened by study staff for contraindications to TMS treatment. TMS will be delivered use the MagVenture TMS machine.

Primary Outcome Measure

Patient reported pain score on SMS text EMA system [ Time Frame: baseline, and post intervention (0 days, 1 week, 2 weeks, 1 month, 3 months, 6 months) ]

Central Contacts

Solomon Hayon, MD
18437927888
[email protected]

Locations (1)

Facility	City	State	ZIP	Site coordinators
Medical University of South Carolina	Charleston	South Carolina	29425	-

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By research site

Medical University of South Carolina· Charleston, SC