Shaping Habitual Impulses For a Tobacco-free Style

Conditions

• ST+ABR
• ST+SHAM
• ST-only

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• ST+ABR — BEHAVIORAL
  ST+ABR participants will complete seven weekly sessions of 15 minutes of computerized training (ABR), followed by a 45-minute session of standard smoking cessation treatment (CBT+NRT). Participants will be instructed to pull or push a joystick depending on the tilt, which will be positive-related or smoking-related images.
• ST+Sham — BEHAVIORAL
  ST+Sham participants will complete seven weekly sessions of 15 minute computerized control sessions (AAT), followed by a 45-minute session of standard smoking cessation treatment (CBT+NRT). Participants will be instructed to pull or push a joystick depending on the tilt, which will be positive-related or smoking-related images.
• ST Only — BEHAVIORAL
  ST Only will consist of 7 weekly 45-minute sessions of standard treatment (CBT+NRT) for smoking cessation.

Study Details

The present investigation aims to assess the efficacy of an innovative and novel smoking cessation intervention that integrates approach bias retraining (ABR) and standard smoking cessation treatment (ST). Participants will be randomized to either: (1) standard smoking cessation treatment and approach bias retraining (ST+ABR); (2) ST+Sham; or (3) ST-only.

Key Dates

Start date

Mar 24, 2026

Status verified

Apr 2026

Primary completion

Nov 1, 2028

Completion

Feb 1, 2029

Study Design

Enrollment

300 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: ST+ABR
  ST+ABR is the combination of standard treatment (cognitive behavioral therapy \[CBT\]+ nicotine replacement therapy \[NRT\]) for smoking cessation based on the most recent clinical practice guideline from the U.S. Department of Health and Human Services, Treating Tobacco Use And Dependence and computerized Approach Bias Retraining (ABR) for smoking cessation.
• Sham Comparator: ST+Sham
  ST+Sham is the combination of standard treatment (CBT+NRT) for smoking cessation based on the most recent clinical practice guideline from the U.S. Department of Health and Human Services, Treating Tobacco Use And Dependence and computerized Sham (Control) training.
• Other: ST Only
  ST Only will consist of standard treatment (CBT+NRT) for smoking cessation, based on the most recent clinical practice guideline from the U.S. Department of Health and Human Services, Treating Tobacco Use And Dependence.

Primary Outcome Measure

7-day Biochemically Verified Point Prevalence Abstinence (PPA) [ Time Frame: 1-week, 2-week, 3-week post-quit, and 1-, 3-, and 6-month follow-ups ]

Central Contacts

• Lorra Garey, PhD
  713-743-8056
  [email protected]
• Ashley Ruiz, B.S.
  713-743-8056
  [email protected]

Locations (1)

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