Effects of Dietary Nitrate in Women With Secondary Amenorrhea

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT07019129
Status
Recruiting
Apply to this trial

Conditions

  • Secondary Amenorrhea

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 44 Years
Healthy Volunteers
Not accepted

Interventions

  • Beetroot Juice - Active — DIETARY_SUPPLEMENT
    Nitrate-rich beetroot juice
  • Placebo Beetroot Juice Without Nitrate — DIETARY_SUPPLEMENT
    Nitrate-poor beetroot juice

Study Details

Excessive exercise, disordered attitudes toward eating, physical and psychological stress, and/or hormonal imbalances may result in cessation of menstruation (secondary amenorrhea). The accompanying lack of estrogen may impair muscle power and oxygen recovery after exercise by reducing nitric oxide levels. The purpose of this study is to determine whether ingestion of beetroot juice containing nitrate, an alternative source of nitric oxide, can help reverse these changes.

Key Dates

Start date
Sep 5, 2025
Status verified
Sep 2025
Primary completion
May 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Placebo
    Nitrate-free beetroot juice
  • Experimental: Nitrate
    Nitrate-rich beetroot juice

Primary Outcome Measure

Maximal knee extensor power [ Time Frame: Approximately 2-3 hours after beetroot ingestion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Indiana University IndianapolisIndianapolisIndiana46202
Andrew R Coggan, PhD
[email protected]
317-274-0656
Madison J Fry, BS
[email protected]
Andrew R Coggan, PhD (PRINCIPAL_INVESTIGATOR)

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Indiana University Indianapolis· Indianapolis, IN