Effect of Watermelon on Cardiometabolic Health

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT07006636
Status
Not Yet Recruiting

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Conditions

  • Cardiometabolic Health Indicators
  • Whole-body Antioxidant Capacity

Eligibility Criteria

Sex
FEMALE
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • Watermelon Juice + liquid meal test at baseline — OTHER
    WMJ will be purchased from a commercially available brand. The liquid meal test will be in the form of the Boost nutritional drink (8 fl.oz., vanilla flavor), which is commercially available.
  • Sweetened placebo beverage +liquid meal test at baseline — OTHER
    The placebo beverage made of water and sugar will match the sugar content provided in 355 ml of WMJ (approximately 10-20 g). The liquid meal test will be in the form of the Boost nutritional drink (8 fl.oz., vanilla flavor), which is commercially available.

Study Details

The purpose of this study is to determine whether consumption of 355 ml of watermelon juice will: 1. improve cardiovascular and overall metabolic health markers like blood pressure, heart rate, stiffness/flexibility of arteries (blood vessels), blood sugar, cholesterol), and gut hormones 2. contribute to the body's ability to protect itself from the potential cell damage caused by harmful chemical compounds (produced when skin is exposed to ultraviolet (UV) B light, for example). This will be evaluated by measuring how resistant skin is to the damage from UVB light exposure, as well as several markers of bodily stress blood and urine. This will be determined immediately after consuming the juice (to evaluate the effects the juice has on health right away), as well as after 4 weeks of daily juice consumption (to evaluate the effects the juice has on health when consumed consistently over time).

Key Dates

Start date
Apr 1, 2026
Status verified
Mar 2026
Primary completion
Sep 1, 2027
Completion
Sep 1, 2027

Study Design

Enrollment
22 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Watermelon Juice + liquid meal test at baseline
    Acute (postprandial) as well as chronic (4 weeks) effects of WMJ consumption will be evaluated. To evaluate acute effects participants will consume a liquid meal test together with WMJ at the beginning of the intervention phase. In addition, the same liquid meal test will be consumed with only WMJ at the end of the intervention phase to assess whether drinking the juice for 4 weeks prior had any effects on postprandial responses.
  • Placebo Comparator: Sweetened placebo beverage + liquid meal test at baseline
    Participants will consume placebo beverage + liquid meal test at baseline. They will then consume watermelon juice daily for 4 weeks. Watermelon juice + liquid meal test will be consumed at endpoint.

Primary Outcome Measure

Postprandial blood pressure [ Time Frame: Baseline and Week 4 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA Center for Human NutritionLos AngelesCalifornia90095
Tatiana Diacova, PhD, MS, RD
[email protected]
310-206-8292
Zhaoping Li, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
UCLA Center for Human Nutrition· Los Angeles, CA

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