Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists

Conditions

• GLP1-R-related Disease
• Upper Endoscopy

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Modified Fasting Guidelines — OTHER
  Patients will follow a full-liquid diet 48 hours prior to their procedure, clear liquid diet 24 hours prior to their procedure, and nothing by mouth (NPO) after midnight on the day of their procedure

Study Details

The aim of this study is to determine whether a modified fasting protocol can reduce the potential risk of aspiration for patients currently prescribed GLP1-RAs.

Key Dates

Start date

Aug 1, 2025

Status verified

Jun 2026

Primary completion

Aug 30, 2026

Completion

Aug 30, 2026

Study Design

Enrollment

150 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Arms

• No Intervention: Normal fasting guidelines and not taking GLP1-RAs
  Patients who are not taking GLP1 RAs (Receptor Agonists) and who will abide by the normal fasting guidelines
• No Intervention: Normal fasting guidelines with GLP1-RAs
  Patients who are taking GLP1 RAs (Receptor Agonists) for either diabetes or weight loss management who will abide by normal fasting guidelines
• Experimental: Modified fasting guidelines with GLP1-RAs
  Patients who are prescribed and taking GLP1 RAs (Receptor Agonists) for either diabetes or weight loss management who follow the modified fasting guidelines. Modified fasting consists of a full-liquid diet 48 hours prior to the procedures, clear liquid diet 24 hours prior to their procedure, and nothing by mouth (NPO) after midnight on the day of their procedure.

Primary Outcome Measure

Gastric contents [ Time Frame: Baseline ]

Central Contacts

• Krishnan Ramanujan, MD
  507-422-4898
  [email protected]

Locations (1)

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