Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

Conditions

• Spontaneous Breathing Trial in ICU

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Pressure Support Ventilation (PSV) — OTHER
  Spontaneous breathing trials will be conducted using the mode pressure support ventilation (PSV) with settings of a pressure support of 5 cmH2O and positive end expiratory pressure (PEEP) 5 cmH2O.
• Automatic tube compensation (ATC) — OTHER
  Spontaneous breathing trials will be conducted using the mode automatic tube compensation (ATC) with settings of 100% tube compensation and a positive end expiratory pressure (PEEP) of 5 cmH2O.

Study Details

For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.

Key Dates

Start date

Jun 1, 2025

Status verified

Jun 2025

Primary completion

Jul 31, 2027

Completion

Aug 31, 2027

Study Design

Enrollment

880 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Arms

• Experimental: Adult Intensive Care Unit (AICU)
• Experimental: Medical Intensive Care Unit (MICU)
• Experimental: Cardiosciences Intensive Care Unit (CSICU)
• Experimental: Neuroscience Intensive Care Unit (NSICU)

Primary Outcome Measure

Reintubation [ Time Frame: Within 48 hours of extubation ]

Central Contacts

• Jie Li, PhD
  312-563-4643
  [email protected]
• Lauren Harnois, MSc
  [email protected]

Locations (1)

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