A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Part of paid clinical trials in Casa Grande, Arizona.

Sponsor
Amgen
Study ID
NCT07005128
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • Extensive Stage Small-cell Lung Cancer
  • Small-cell Lung Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • Tarlatamab — DRUG
    Tarlatamab will be administered as an intravenous (IV) infusion.
  • Durvalumab — DRUG
    Durvalumab will be administered as an IV infusion.
  • Carboplatin — DRUG
    Carboplatin will be administered as an IV infusion.
  • Etoposide — DRUG
    Etoposide will be administered as an IV infusion.

Study Details

The main objective of the study is to compare the efficacy of tarlatamab in combination with durvalumab, carboplatin and etoposide to the combination of durvalumab, carboplatin and etoposide on prolonging overall survival (OS).

Key Dates

Start date
Aug 18, 2025
Status verified
Jun 2026
Primary completion
Jan 4, 2029
Completion
Jul 15, 2029

Study Design

Enrollment
330 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Tarlatamab + Durvalumab + Carboplatin + Etoposide
    Participants will receive tarlatamab in combination with durvalumab, carboplatin and etoposide for 4 cycles followed by tarlatamab and durvalumab.
  • Active Comparator: Durvalumab + Carboplatin + Etoposide
    Participants will receive durvalumab, carboplatin and etoposide for 4 cycles followed by durvalumab.

Primary Outcome Measure

Overall Survival (OS) [ Time Frame: Up to approximately 3.5 years ]

Central Contacts

Locations (43)

FacilityCityStateZIPSite coordinators
Cancer and Blood Specialists of ArizonaCasa GrandeArizona85222-
City of Hope Cancer Center PhoenixGoodyearArizona85338-
Saint Bernards Medical CenterJonesboroArkansas72401-
Translational Research in Oncology US Inc, Trio Central PharmacyLos AngelesCalifornia90095-
University of California Los AngelesSanta MonicaCalifornia90404-
Presbyterian Intercommunity Hospital Health Whitter HospitalWhittierCalifornia90602-
Colorado West Healthcare System dba Grand Valley OncologyGrand JunctionColorado81505-
Yale New Haven HospitalNew HavenConnecticut06510-
Eastern Connecticut Hematology and Oncology AssociatesNorwichConnecticut06360-
Cancer Specialists of North Florida - SouthpointJacksonvilleFlorida32256-
Orlando Health Cancer InstituteKissimmeeFlorida34744-
City of Hope AtlantaNewnanGeorgia30265-
University of Illinois ChicagoChicagoIllinois60612-
Cancer Care Specialists of IllinoisDecaturIllinois62526-
Midwestern Regional Medical Center dba City of Hope ChicagoRockfordIllinois61108-
Hematology Oncology of IndianaIndianapolisIndiana46260-
Indiana University Melvin and Bren Simon Cancer CenterIndianapolisIndiana46202-
Cancer Center of Kansas, Heritage Plaza Medical BuildingWichitaKansas67214-
New England Cancer SpecialistsWestbrookMaine04092-
Dana Farber Cancer InstituteBostonMassachusetts02215-
Minnesota Oncology Hematology PAEdinaMinnesota55435-
Allina Health System dba Allina Health Cancer InstituteMinneapolisMinnesota55407-
Mayo ClinicRochesterMinnesota55905-
Cancer Partners of NebraskaLincolnNebraska68516-
Nebraska Cancer SpecialistsOmahaNebraska68130-
New York Oncology Hematology PCAlbanyNew York12206-
New York Cancer and Blood SpecialistsShirleyNew York11967-
Oncology Hematology Care, IncCincinnatiOhio45242-
University Hospitals Cleveland Medical CenterClevelandOhio44106-
Willamette Valley Cancer Institute and Research Center - EugeneEugeneOregon97401-
Kaiser Permanente Medical CenterPortlandOregon97227-
Baptist Cancer CenterMemphisTennessee38120-
United States Oncology Regulatory Affairs Corporate OfficeNashvilleTennessee37203-
Texas Oncology - Dallas Fort WorthDallasTexas75246-
Oncology ConsultantsHoustonTexas77030-
US Oncology Research Investigational Products CenterIrvingTexas75063-
Texas Oncology Northeast TexasTylerTexas75702-
University of Texas Health Science Center at TylerTylerTexas75701-
Virginia Cancer Specialists PCFairfaxVirginia22031-
Virginia Oncology AssociatesNorfolkVirginia23502-
Swedish Cancer Institute Medical OncologySeattleWashington98104-
Northwest Medical Specialties, PLLCTacomaWashington98405-
West Virginia University Health Sciences CenterMorgantownWest Virginia26506-

Find similar trials in Casa Grande, AZ

By research site
Cancer and Blood Specialists of Arizona· Casa Grande, AZCity of Hope Cancer Center Phoenix· Goodyear, AZSaint Bernards Medical Center· Jonesboro, ARTranslational Research in Oncology US Inc, Trio Central Pharmacy· Los Angeles, CAUniversity of California Los Angeles· Santa Monica, CAPresbyterian Intercommunity Hospital Health Whitter Hospital· Whittier, CA

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