Neural Control and Mechanosensation in Spine Muscle

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT07003802
Status
Enrolling By Invitation

Conditions

  • Disc Herniation
  • Low Back Pain and Core Muscle

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Resistance exercise — BEHAVIORAL
    An acute bout of a 3 minute resistance exercise will be performed using a lumbar extension exercise machine

Study Details

Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization. Lumbar spine muscle is compromised in LBP, and do, and do not, respond to exercise based physical therapy program depending on measurements representing activation capacity of lumbar muscle. Here, we will characterize the neurological and muscle specific features that may contribute to limited activation in an attempt to identify sources of resistance to recovery in patients with chronic disc injury and identify precision rehabilitation approaches for this complex population of individuals.

Key Dates

Start date
Jul 1, 2025
Status verified
Apr 2026
Primary completion
May 1, 2029
Completion
May 1, 2030

Study Design

Enrollment
152 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Resistance exercise
    An acute bout of a 3 minute resistance exercise will be performed using a lumbar extension exercise machine

Primary Outcome Measure

RMS amplitude of paraspinal muscle EMG [ Time Frame: Baseline ]

Locations (1)

FacilityCityStateZIPSite coordinators
UC San DiegoLa JollaCalifornia92093-

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By research site
UC San Diego· La Jolla, CA

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