Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)

Conditions

• Community Acquired Pneumonia
• Community Acquired Pneumonia (CAP)

Eligibility Criteria

Sex

ALL

Age

12 Months - 71 Months

Healthy Volunteers

Not accepted

Interventions

• Immediate Antibiotic Prescribing Group Instructions — OTHER
  Children randomized to the immediate antibiotic prescribing group will receive an antibiotic prescription with instructions to fill and administer the antibiotics.
• Safety Net Antibiotic Prescribing (SNAP) Group Instructions — OTHER
  For children randomized to the SNAP group, their parents or guardians will receive a prescription for antibiotics, but will be told not to administer the antibiotic unless their child's symptoms show no improvement at 72 hours or worsen within 72 hours.

Study Details

The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with community-acquired pneumonia get better from their illness. The main aims of this study are: * To compare the effectiveness of SNAP versus immediate antibiotic prescribing in children with mild community-acquired pneumonia (CAP) * To identify which patient groups benefit most from the SNAP strategy * To identify factors that shape implementation of each prescribing strategy. Researchers will compare the SNAP strategy (where parents or guardians are instructed to give antibiotics only if their child is not improving after 72 hours, or sooner if they are worsening) to the immediate antibiotic prescribing strategy (where parents or guardians are instructed to give the antibiotics right after their healthcare visit) to see if one strategy is more effective than the other. Participants will be randomly assigned to either the immediate antibiotic group or the SNAP group at enrollment. Participation lasts 14 days with follow-up surveys at 4, 7, and 14 days after enrollment.

Key Dates

Start date

Sep 9, 2025

Status verified

Jan 2026

Primary completion

Jun 30, 2029

Completion

Jul 16, 2029

Study Design

Enrollment

2,000 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Active Comparator: Immediate Antibiotic Prescribing
  For participants randomized to this arm, a prescription is filled and the antibiotic is administered right after the index visit.
• Other: Safety Net Antibiotic Prescribing (SNAP)
  For participants randomized to this arm, a prescription is provided, but the patient is instructed not to take the antibiotic unless the child is not improving at 72 hours or sooner if getting worse.

Primary Outcome Measure

Clinical Improvement [ Time Frame: From enrollment to day 7 ]

Central Contacts

• Todd Florin, MD, MSCE
  312-227-6675
  [email protected]
• Julia Szymczak, PhD
  [email protected]

Locations (4)

Find similar trials in Atlanta, GA

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