Atacicept in Multiple Glomerular Diseases

Part of paid clinical trials in Brisbane, California.

Sponsor
Vera Therapeutics, Inc.
Study ID
NCT06983028
Phase
PHASE2
Status
Recruiting
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Conditions

  • FSGS
  • IgAN
  • MCD
  • Nephrotic Syndrome
  • pMN

Eligibility Criteria

Sex
ALL
Age
10 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Atacicept — DRUG
    Atacicept 150 mg SC QW via pre-filled syringe

Study Details

The purpose of this study is to evaluate the safety and tolerability of atacicept in adult and adolescent participants and to measure the effect in reducing proteinuria and preserving renal function.

Key Dates

Start date
Jul 7, 2025
Status verified
Jan 2026
Primary completion
Nov 30, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: IgAN or IgAVN
    Adult and pediatric patients with biopsy proven IgAN or IgAVN with varied severity of proteinuria and kidney function beyond what is currently included in most clinical trials. Adults with post-transplant IgAN recurrence are also included.
  • Experimental: pMN
    Adults with biopsy-proven pMN associated with anti-PLA2R antibodies at low risk of spontaneous remission, or experiencing recurrent or resistant disease.
  • Experimental: Primary Nephrotic Syndrome (MCD/FSGS)
    Adults with biopsy-proven primary MCD or FSGS and evidence of anti-nephrin antibodies. Children with frequently relapsing, steroid-dependent, or non-genetic steroid-resistant nephrotic syndrome with evidence of anti-nephrin antibodies.

Primary Outcome Measure

AE profile and results of routine clinical and laboratory tests [ Time Frame: Baseline until end of study: 52 + 26 Weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vera TherapeuticsBrisbaneCalifornia94005
Brisbane, California
[email protected]
(650)770-0077

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By research site
Vera Therapeutics· Brisbane, CA

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