A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors

Part of paid clinical trials in San Francisco, California.

Sponsor
Exelixis
Study ID
NCT06952010
Phase
PHASE1
Status
Recruiting
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Conditions

  • Advanced Solid Tumor
  • Immune Sensitive Tumor
  • Metastatic Solid Tumor
  • Solid Tumor

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • XB628 — BIOLOGICAL
    Intravenous infusion(s)

Study Details

This is a phase 1, first-in-human, open-label, dose-escalation study of XB628, a first-in-class bispecific antibody natural killer (NK) cell engager that targets NK group 2 member A (NKG2A), an inhibitory receptor on NK cells, and programmed cell death-ligand 1 (PD-L1).

Key Dates

Start date
May 1, 2025
Status verified
May 2026
Primary completion
May 31, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
75 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: XB628
    Group(s) of participants with recurrent advanced or metastatic solid tumors will receive escalating dose levels doses of XB628.

Primary Outcome Measure

Number of Participants with Dose Limiting Toxicities (DLTs) [ Time Frame: 21 days ]

Central Contacts

  • Exelixis Clinical Trials
    1-888-EXELIXIS (888-393-5494)
    [email protected]
  • Backup or International
    650-837-7400

Locations (11)

FacilityCityStateZIPSite coordinators
Exelixis Clinical Site #5San FranciscoCalifornia94158-
Exelixis Clinical Site #4New HavenConnecticut06520-
Exelixis Clinical Site #8TampaFlorida33612-
Exelixis Clinical Site #10BostonMassachusetts02114-
Exelixis Clinical Site #11BostonMassachusetts02114-
Exelixis Clinical Site #6St LouisMissouri63108-
Exelixis Clinical Site #7New YorkNew York10029-
Exelixis Clinical Site #1HickoryNorth Carolina28602-
Exelixis Clinical Site #3NashvilleTennessee37203-
Exelixis Clinical Site #9HoustonTexas77030-
Exelixis Clinical Site #2San AntonioTexas78229-

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