Pupillometry in Delayed Sleep Wake Phase Disorder

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT06949644
Status
Recruiting
Apply to this trial

Conditions

  • Delayed Sleep-Wake Phase Disorder

Eligibility Criteria

Sex
ALL
Age
16 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Light and Citalopram — COMBINATION_PRODUCT
    Participants will receive placebo or citalopram, followed by bright light exposure

Study Details

The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is: Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? Participants will complete activity and melatonin testing at home to determine their circadian timing. This will be followed by an eye test looking at the pupil response to different light stimuli. A subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. During one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.

Key Dates

Start date
Sep 1, 2025
Status verified
Jun 2026
Primary completion
Jul 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
220 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: DSWPD
    Placebo or Citalopram followed by bright light (all participants will receive both interventions in random order).

Primary Outcome Measure

Melatonin suppression [ Time Frame: 8 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Northwestern UniversityChicagoIllinois60611
Research Assistant
[email protected]
312-908-1024

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By research site
Northwestern University· Chicago, IL

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