Assessing the Impact of dTMS on Neural Targets Associated With Alcohol Use Disorder

Part of paid clinical trials in Palo Alto, California.

Sponsor
Stanford University
Study ID
NCT06949423
Status
Recruiting
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Conditions

  • Alcohol Use Disorder (AUD)
  • Transcranial Magnetic Stimilation

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Deep Transcranial Magnetic Stimulation (dTMS) H7 coil - Active — DEVICE
    The study will utilize the H7 coil to administer active Deep Transcranial Magnetic Stimulation (dTMS) to the dorsal anterior cingulate cortex (dACC), a core salience network node.
  • Deep Transcranial Magnetic Stimulation (dTMS) H7 coil - Sham — DEVICE
    The study will utilize an identical protocol using the H7 coil to administer a sham condition.

Study Details

The purpose of this study is to evaluate the efficacy of deep transcranial magnetic stimulation as a treatment for Veterans with Alcohol Use Disorder (AUD) to decrease the exceedingly high rate of relapse associated with this condition.

Key Dates

Start date
Dec 17, 2025
Status verified
Feb 2026
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Active dTMS
    Participants will receive 30 sessions of active-dTMS to the dACC/mPFC with the H7 coil, administered 3 times per day over 10 consecutive business days. Each treatment visit will last approximately 30 minutes in total.
  • Sham Comparator: Sham dTMS
    Participants will receive 30 sham dTMS sessions, administered 3 times per day over 10 consecutive business days. Each treatment visit will last approximately 30 minutes in total.

Primary Outcome Measure

Change in Dorsal Anterior Cingulate Cortex Function (dACC) Activation During the FACES Task, Measured via fMRI [ Time Frame: 1-4 days post treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
VA Palo Alto Health Care SystemPalo AltoCalifornia94304
Eileen G Fischer, BS
[email protected]
210-993-2065
Claudia B Padula, PhD (PRINCIPAL_INVESTIGATOR)
Michelle R Madore, PhD (PRINCIPAL_INVESTIGATOR)

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