A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT06948422
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Orforglipron — DRUG
    Administered orally.
  • Placebo — DRUG
    Administered orally.

Study Details

The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of hypertension in participants with obesity or overweight.

Key Dates

Start date
Apr 30, 2025
Status verified
May 2026
Primary completion
Sep 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
974 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING

Arms

  • Experimental: Orforglipron (GZL1)
    Participants will receive orforglipron orally or placebo.
  • Experimental: Orforglipron (GZL2)
    Participants will receive orforglipron orally or placebo.

Primary Outcome Measure

Number of Participants Allocated to Each ISA [ Time Frame: Week -8 to Week 0 ]

Locations (29)

FacilityCityStateZIPSite coordinators
Elite Clinical Studies, LLCPhoenixArizona85018-
Valley Clinical Trials, Inc.CovinaCalifornia91723-
Valley Clinical Trials, Inc.NorthridgeCalifornia91325-
Chase Medical Research, LLCWaterburyConnecticut06708-
Excel Medical Clinical TrialsBoca RatonFlorida33434-
Care Access - BrandonBrandonFlorida33510-
Northeast Research Institute - Downtown OfficeJacksonvilleFlorida32204-
Care Access - St. PetersburgSt. PetersburgFlorida33710-
East-West Medical Research InstituteHonoluluHawaii96814-
Ascension Saint Agnes Heart CareBaltimoreMaryland21229-
Sinai Hospital Of BaltimoreBaltimoreMaryland21209-
Lucida Clinical TrialsNew BedfordMassachusetts02740-
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroyMichigan48098-
StudyMetrix ResearchCity of Saint PetersMissouri63303-
Excel Clinical Research, LLCLas VegasNevada89109-
Palm Research Center SunsetLas VegasNevada89148-
Rochester Clinical Research, LLCRochesterNew York14609-
Remington-Davis, IncColumbusOhio43215-
PriMED Clinical ResearchDaytonOhio45429-
Advanced Research Institute - TigardTigardOregon97223-
Care Access - MauldinMauldinSouth Carolina29662-
Dallas Heart and Vascular Consultants, PADuncanvilleTexas75137-
Texas Institute of Cardiology, PAMcKinneyTexas75071-
North Hills Family Medicine/North Hills Medical ResearchNorth Richland HillsTexas76180-
Advanced Research InstituteOgdenUtah84405-
Carient Heart & Vascular - ManassasManassasVirginia20109-
Health Research of Hampton Roads, Inc.Newport NewsVirginia23606-
National Clinical Research, IncRichmondVirginia23294-
Eastside Research AssociatesRedmondWashington98052-

Find similar trials in Phoenix, AZ

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
Elite Clinical Studies, LLC· Phoenix, AZValley Clinical Trials, Inc.· Covina, CAValley Clinical Trials, Inc.· Northridge, CAChase Medical Research, LLC· Waterbury, CTExcel Medical Clinical Trials· Boca Raton, FLCare Access - Brandon· Brandon, FL

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