Inorganic Nitrate as a Treatment for ANOCA: NO-ANOCA

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT06948201
Status
Not Yet Recruiting

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Conditions

  • Angina Patients With Non-obstructive Coronary Artery Disease
  • Coronary Microvascular Dysfunction (CMD)

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • 70mL Nitrate Rich Beetroot Juice followed by placebo (Nitrate depleted beetroot juice) — DIETARY_SUPPLEMENT
    70mL Nitrate Rich Beetroot Juice for 14 days followed by placebo (Nitrate depleted beetroot juice) for 14 days
  • Placebo (70 mL Nitrate depleted beetroot juice) followed by 70mL Nitrate Rich Beetroot Juice — DIETARY_SUPPLEMENT
    Placebo (70 mL Nitrate depleted beetroot juice) for 14 days followed by 70mL Nitrate Rich Beetroot Juice for 14 days

Study Details

The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD. The main questions it aims to answer are: AIM 1: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase cardiac perfusion and improve quality of life compared to placebo. AIM 2: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase physical fitness and reduce angina and dyspnea symptoms compared to placebo. Exploratory AIM 3: Test the hypothesis that fourteen days of nitrate rich beetroot juice will improve vascular health and function. Participants will: * Take study beverage for 4 weeks total. * Stress Cardiac magnetic resonance imaging and 12 lead electrocardiograms * Complete questionnaires * Cycling exercise test * Non invasive vascular testing * Blood draws

Key Dates

Start date
May 31, 2025
Status verified
Apr 2025
Primary completion
May 31, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
8 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Other: Beetroot juice followed by placebo
    70mL Nitrate Rich Beetroot Juice for 14 days followed by placebo (70mL nitrate depleted beetroot juice) for 14 days
  • Other: Placebo followed by Beetroot juice
    Placebo (70 mL nitrate depleted beetroot juice) for 14 days followed by Nitrate rich Beetroot juice for 14 days

Primary Outcome Measure

Change in Coronary Flow Reserve [ Time Frame: From enrollment to day 14 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22903
Shuo Wang
[email protected]
434-982-1058
Emily Planas
[email protected]
434-982-1058
Patricia Rodriguez-Lozano, MD (PRINCIPAL_INVESTIGATOR)
Jason Allen, Ph.D. (SUB_INVESTIGATOR)

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University of Virginia· Charlottesville, VA

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