Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis

Part of paid clinical trials in Elmsford, New York.

Sponsor
Montefiore Medical Center
Study ID
NCT06946550
Status
Recruiting
Apply to this trial

Conditions

  • Scarring Alopecia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 1470nm non-ablative fractional laser — DEVICE
    Patients with scarring alopecia will be treated with the non-ablative Sciton HALO laser (1470nm).

Study Details

The goal of this clinical trial is to evaluate the effectiveness of a non-ablative 1470 nm laser in treating scarring alopecia in adults. The study will also investigate the biochemical molecular pathways involved in laser therapy by analyzing hair follicle gene expression before and after laser treatment. The main questions it aims to answer are: 1. Does a non-ablative laser work to effectively treat scarring alopecia? 2. What molecular pathways are associated with the laser's effects on hair follicles in scarring alopecia? Participants with scarring alopecia will: * Receive 3 laser treatments, spaced 1 month apart (Month 1, Month 2, Month 3), and attend 5 follow-up visits (Month 4, Month 6, Month 9, Month 12 and Month 15) * Have hair follicle samples collected via hair plucking of 10 hairs prior to the start and 1-month post-completion of laser treatments for gene expression analysis of inflammatory and fibrosis pathways implicated in scarring alopecia. Hair samples will be de-identified and kept anonymous. * Fill out questionnaires at each visit * Keep a diary of any side effects from laser treatments

Key Dates

Start date
Dec 9, 2025
Status verified
Dec 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
5 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Scarring alopecia
    Patients with scarring alopecia will receive 3 treatments with the non-ablative Sciton HALO laser (1470nm). Each laser treatment will take approximately 10 to 15 minutes per subject.

Primary Outcome Measure

Clinician Global Aesthetic Improvement Scale [ Time Frame: Month 2, Month 3, Month 4, Month 6, Month 9, Month 12, Month 15 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Montefiore Einstein Advanced CareElmsfordNew York10523
Anika Jallorina
[email protected]
914-457-4130
Kseniya Kobets, MD (PRINCIPAL_INVESTIGATOR)
Janet Choi, BS (SUB_INVESTIGATOR)
Beth N McLellan, MD (SUB_INVESTIGATOR)
Kosaku Shinoda, PhD (SUB_INVESTIGATOR)
Anika Jallorina, BS (SUB_INVESTIGATOR)

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Montefiore Einstein Advanced Care· Elmsford, NY

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