Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged

Part of paid clinical trials in Lincoln, Nebraska.

Sponsor
University of Nebraska
Study ID
NCT06943846
Status
Recruiting
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Conditions

  • Edentulism

Eligibility Criteria

Sex
ALL
Age
14 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Platelet-rich fibrin (PRF) — PROCEDURE
    Platelet-rich fibrin added to extraction socket

Study Details

The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.

Key Dates

Start date
May 1, 2025
Status verified
Jan 2026
Primary completion
May 31, 2026
Completion
May 31, 2027

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Aged Participants Treated with Platelet-rich Fibrinogen
    Participants aged 50 to 80 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.
  • No Intervention: Aged Control
    Participants aged 50 to 80 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.
  • Active Comparator: Young Participants Treated with Platelet-rich Fibrinogen
    Participants aged 14 to 18 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.
  • No Intervention: Young Control
    Participants aged 14 to 18 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

Primary Outcome Measure

Cytokine Concentration [ Time Frame: Baseline and two weeks post-extraction ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Nebraska Medical Center College of DentistryLincolnNebraska68358
Amy C Killeen, DDS, MS
[email protected]
402-472-7948

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By research site
University of Nebraska Medical Center College of Dentistry· Lincoln, NE

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