Vapocoolant Spray to Reduce Pain With Nexplanon Insertion

Conditions

• Reducing Pain With Nexplanon Implant Insertion

Eligibility Criteria

Sex

FEMALE

Age

14 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Vapocoolant spray — DEVICE
  Pain Ease will be used per manufacturer instruction, applying the spray for 5 seconds or until the skin turns white, whichever occurs first.
• Placebo — OTHER
  Nature's Tears will be applied to the arm as a placebo spray

Study Details

The purpose of this study is to assess if Pain Ease vapocoolant spray decreases pain associated with lidocaine injection during Nexplanon insertion procedures.

Key Dates

Start date

Jun 16, 2025

Status verified

Jan 2026

Primary completion

Apr 1, 2026

Completion

May 1, 2026

Study Design

Enrollment

70 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• Experimental: Vapocoolant Spray
  This is the study arm. Participants in this arm of the study will receive Pain Ease vapocoolant spray during their Nexplanon implant insertion in the arm. They will receive the spray on their arm right before lidocaine injection is administered for Nexplanon insertion procedure. Pain Ease vapocoolant spray is FDA approved for use on skin prior to common needle-stick procedures like intravenous (IV) starts and vaccines. The investigators will use the spray in a similar fashion, to help with the pain of lidocaine injection during Nexplanon insertion procedures. Physicians will do the Nexplanon procedure before any other procedures if patient has multiple procedures scheduled the same day.
• Placebo Comparator: Nature's Tears
  This is the placebo. This group will receive Nature's Tears, which is a saline spray that does not offer analgesic effects.

Primary Outcome Measure

Pain with lidocaine injection [ Time Frame: Immediately after lidocaine injection ]

Central Contacts

• Sarah Murayama, MD
  808-783-0298
  [email protected]
• Mary Tschann, PhD
  808-375-3785
  [email protected]

Locations (3)

Find similar trials in Honolulu, HI