Dexamethasone for Ureteral STent Symptoms (DUSTS)

Conditions

• Ureteral Stent-Related Symptom

Eligibility Criteria

Sex

ALL

Age

18 Years - 70 Years

Healthy Volunteers

Not accepted

Interventions

• Dexamethasone Sodium Phosphate Injection 20 mg — DRUG
  dexamethasone 20 mg diluted in 50 mL of normal saline administered by intravenous drip after induction of anesthesia
• Dexamethasone Sodium Phosphate Injection 4mg — DRUG
  dexamethasone 4 mg diluted in 50 mL of normal saline administered by intravenous drip after induction of anesthesia

Study Details

The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The main question it aims to answer is: 1\) Does high-dose steroid change the quality of life score on day 2 after surgery Researchers will compare high-dose of dexamethasone (20 mg) to a standard dose of dexamethasone (4 mg) to see if a higher dose of the drug will help with urinary symptoms and pain Participants will: 1. randomly receive 20 mg or 4 mg of dexamethasone (20 mg) at the time of surgery 2. fill out a questionnaire day 1 and day 2 after surgery 3. fill out a medication diary for one week after surgery 4. visit the clinic on day 2 after surgery for checkup 5. visit the clinic on day 4-7 after surgery for check up

Key Dates

Start date

Jun 30, 2026

Status verified

May 2026

Primary completion

Dec 31, 2026

Completion

Apr 30, 2027

Study Design

Enrollment

70 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Treatment Arm
  Dexamethasone 20 mg
• Active Comparator: Control Arm
  Dexamethasone 4 mg

Primary Outcome Measure

Global Quality of Life Score of Ureteral Stent Symptom Questionnaire (USSQ) [ Time Frame: Day 2 after surgery ]

Central Contacts

• Farida Tufail
  713-269-0186
  [email protected]
• Johnny Su, MD
  [email protected]

Locations (1)

Find similar trials in Houston, TX

Related Studies

• Impact of Ureteral Stent and Sheaths Size on Post-Operative Pain
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