Direct vs. Conventional SLT in Open-Angle Glaucoma: A RCT

Conditions

• GLAUCOMA 1, OPEN ANGLE, D (Disorder)

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• DSLT treatment for Open-Angle Glaucoma — DEVICE
  This intervention aims to determine the efficacy and safety of Direct Selective Laser Trabeculoplasty (DSLT) in reducing intraocular pressure in patients with open-angle glaucoma.
• SLT treatment for Open-Angle Glaucoma — DEVICE
  To determine the efficacy and safety of using Selective Laser Trabeculoplasty for treatment of open-angle glaucoma.

Study Details

This study compares two laser treatments for open-angle glaucoma: Selective Laser Trabeculoplasty (SLT) and Direct Selective Laser Trabeculoplasty (DSLT). SLT is a widely used procedure that requires a manual technique with a goniolens, while DSLT is a new, automated, non-contact method using the Eagle system. The study will evaluate whether DSLT is as effective as SLT in reducing intraocular pressure (IOP). Participants will be randomly assigned to receive either treatment and will be monitored over 12 months to assess changes in IOP, medication use, and safety outcomes. The goal is to determine if the simpler DSLT procedure can provide similar results to SLT, potentially improving patient comfort and access to glaucoma care.

Key Dates

Start date

Aug 7, 2025

Status verified

Sep 2025

Primary completion

Aug 31, 2026

Completion

Aug 31, 2026

Study Design

Enrollment

51 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Other: Arm 1- DSLT (Direct Selective Laser Trabeculoplasty)
  DSLT is a well-established non-contact laser application that does not require a gonioscopy lens, reducing the risk of corneal damage and inflammation.
• Other: Arm 2- Selective Laser Trabeculoplasty (SLT)
  SLT is a widely used and effective laser therapy to lower intraocular pressure that requires operator expertise and carries risks of mild inflammation, corneal damage and discomfort. This is a standard laser system that requires the use of a gonioscopy lens placed on the cornea to administer.

Primary Outcome Measure

Primary Endpoint [ Time Frame: 6 months ]

Locations (1)

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