BID LTM Digital Intervention in Aging

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06916221
Status
Recruiting
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Conditions

  • Inhibitory Control
  • Long-Term Memory
  • Mild Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
60 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Long Term Memory — BEHAVIORAL
    Tablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands.
  • Worder — BEHAVIORAL
    Tablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game.

Study Details

Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants. Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function. Participants will conduct study activities remotely (e.g., at-home): 1. Baseline Assessment. Complete a series of cognitive assessments and surveys. 2. Intervention. Engage in a digital intervention for up to 8 weeks. 3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment. 4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

Key Dates

Start date
Aug 20, 2025
Status verified
Mar 2026
Primary completion
Jan 31, 2028
Completion
Jul 31, 2028

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Long Term Memory
    Multi-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge.
  • Active Comparator: Worder
    Multi-session cognitive intervention as a computer game that presents a word puzzle.

Primary Outcome Measure

MDT change in recognition memory [ Time Frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San FrancsicoSan FranciscoCalifornia94158-

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