Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

Conditions

• Laceration of Skin

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Lidocaine — DRUG
  Lidocaine local infiltration
• Diphenhydramine — DRUG
  Diphenhydramine local infiltration

Study Details

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

Key Dates

Start date

Sep 3, 2025

Status verified

Jan 2026

Primary completion

Jun 30, 2027

Completion

Jun 30, 2028

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Lidocaine
• Experimental: Diphenhydramine

Primary Outcome Measure

Sensation reduction [ Time Frame: Measurements will be recorded before drug injection and immediately after laceration repair. ]

Locations (1)

Find similar trials in Boynton Beach, FL

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