HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

Part of paid clinical trials in The Bronx, New York.

Sponsor
Montefiore Medical Center
Study ID
NCT06899152
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • HepQuant DuO — DIAGNOSTIC_TEST
    HepQuant DuO is a quantitative liver function test. It assesses cholate uptake, a liver specific function. Cholate is a naturally occurring substance that is cleared by the liver. Cholate uptake reflects the health of liver cells.
  • Multiparametric MRI Scans — OTHER
    Standard of care

Study Details

This is a pilot and feasibility study assessing the role of quantitative multiparametric MRI and blood-based biomarkers for the measurement of liver function in patients receiving radiation therapy for liver cancer, including hepatocellular carcinoma (HCC), cholangiocarcinoma, or liver metastases regardless of primary histology, that are undergoing photon radiation either in the de-novo or re-irradiation setting. The goal of this study is to prospectively evaluate the feasibility of using quantitative multiparametric MRI to monitor liver function at baseline and following liver radiation therapy.

Key Dates

Start date
Jul 16, 2025
Status verified
Jul 2025
Primary completion
Jul 31, 2031
Completion
Jul 31, 2031

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Multiparametric MRI scans and HepQuant Duo Test
  • Active Comparator: Multiparametric MRI scans only

Primary Outcome Measure

Feasibility of Quantitative MRI [ Time Frame: Approximately 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Montefiore Medical CenterThe BronxNew York10467
Rikin Gandhi
[email protected]
Jill Salvi
[email protected]
857-399-5039
Rafi Kabarriti, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in The Bronx, NY

By condition
Liver cancer
By specialty
OncologyGI oncologyHepatology
By research site
Montefiore Medical Center· The Bronx, NY

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