A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT06897475
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • LY3457263 — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

Key Dates

Start date
Mar 28, 2025
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Jan 31, 2027

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: LY3457263 Dose 1
    Participants will receive LY3457263 subcutaneously (SC)
  • Experimental: LY3457263 Dose 2
    Participants will receive LY3457263 SC
  • Experimental: LY3457263 Dose 3
    Participants will receive LY3457263 SC
  • Placebo Comparator: Placebo
    Participants will receive placebo SC

Primary Outcome Measure

Change from Baseline in Hemoglobin A1c (HbA1c) [ Time Frame: Baseline, Week 24 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (25)

FacilityCityStateZIPSite coordinators
Helios Clinical Research - PhoenixPhoenixArizona85028
480-372-5996
David Francyk (PRINCIPAL_INVESTIGATOR)
Wolverine Clinical TrialsSanta AnaCalifornia92706
714-617-2426
Behnam Khaleghi (PRINCIPAL_INVESTIGATOR)
Renstar Medical ResearchOcalaFlorida34471
352-629-5800
David Oliver (PRINCIPAL_INVESTIGATOR)
Oviedo Medical ResearchOviedoFlorida32765
407-977-2705
Bradley Block (PRINCIPAL_INVESTIGATOR)
Balanced Life Health Care Solutions/SKYCRNGLawrencevilleGeorgia30046
770-696-4541
Nadia Cameron, MD (PRINCIPAL_INVESTIGATOR)
Physicians Research AssociatesLawrencevilleGeorgia30046
678-252-2375
Ola Odugbesan (PRINCIPAL_INVESTIGATOR)
Rophe Adult and Pediatric Medicine/SKYCRNGUnion CityGeorgia30291
470-317-3604
Dwight Blake (PRINCIPAL_INVESTIGATOR)
North Georgia Clinical ResearchWoodstockGeorgia30189
678-494-5735
Bram Wieskopf (PRINCIPAL_INVESTIGATOR)
Elite Clinical TrialsRexburgIdaho83440
208-356-8977
Brian Beesley (PRINCIPAL_INVESTIGATOR)
Investigators Research GroupBrownsburgIndiana46112
317-852-8280
Kenneth Maynard (PRINCIPAL_INVESTIGATOR)
Clinical Research of PhiladelphiaPenningtonNew Jersey08534
215-676-6696
Taher Modarressi (PRINCIPAL_INVESTIGATOR)
NYC Research INCLong Island CityNew York11106
516-574-9232
Anastasios Manessis (PRINCIPAL_INVESTIGATOR)
Richmond University Medical CenterStaten IslandNew York10310
718-818-2430
Philip Otterbeck (PRINCIPAL_INVESTIGATOR)
Southgate Medical GroupWest SenecaNew York14224
716-712-1004
Brian Snyder (PRINCIPAL_INVESTIGATOR)
Lucas Research, Inc.Morehead CityNorth Carolina28557
252-222-5700
Kathryn Lucas (PRINCIPAL_INVESTIGATOR)
Shelby Clinical ResearchShelbyNorth Carolina28150
980-552-9230
Christian Martin (PRINCIPAL_INVESTIGATOR)
Providence Health Partners-Center for Clinical ResearchDaytonOhio45439
937-297-8994
Paul Opsahl (PRINCIPAL_INVESTIGATOR)
Alliance for Multispecialty Research, LLCNormanOklahoma73069
405-701-8999
Lisa Connery (PRINCIPAL_INVESTIGATOR)
Frontier Clinical Research, LLCScottdalePennsylvania15683
724-220-5281
Tiffany Pluto (PRINCIPAL_INVESTIGATOR)
Juno ResearchHoustonTexas77040
713-779-5494
Damaris Vega (PRINCIPAL_INVESTIGATOR)
Southern Endocrinology AssociatesMesquiteTexas75149
214-693-0904
Sumana Gangi (PRINCIPAL_INVESTIGATOR)
Texas Diabetes & Endocrinology, P.A.Round RockTexas78681
512-334-3505
Srujana Yada (PRINCIPAL_INVESTIGATOR)
Consano Clinical Research, LLCShavano ParkTexas78231
210-545-4900
Michelle Welch (PRINCIPAL_INVESTIGATOR)
Texas Valley Clinical ResearchWeslacoTexas78596
956-431-8090
Eduardo Luna (PRINCIPAL_INVESTIGATOR)
Eastside Research AssociatesRedmondWashington98052
425-869-6828
Chad Crystal (PRINCIPAL_INVESTIGATOR)

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Helios Clinical Research - Phoenix· Phoenix, AZWolverine Clinical Trials· Santa Ana, CARenstar Medical Research· Ocala, FLOviedo Medical Research· Oviedo, FLBalanced Life Health Care Solutions/SKYCRNG· Lawrenceville, GAPhysicians Research Associates· Lawrenceville, GA

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