Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Conditions

• ANOCA - Angina With Non-obstructive Coronary Arteries
• INOCA (Ischemia With Non Obstructive Coronary Artery Disease)

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Coronary reactivity testing with and without nitrates — DIAGNOSTIC_TEST
  CRT will be performed in the left and right coronary arteries. Measurements will be obtained in each of the coronaries first without intracoronary nitrates followed by a dose of 200-500 mcg of intracoronary nitrates and repeat measurements.

Study Details

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Key Dates

Start date

May 21, 2025

Status verified

Mar 2026

Primary completion

May 1, 2027

Completion

Jun 1, 2027

Study Design

Enrollment

50 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Arms

• Experimental: Coronary Reactivity Testing with and without intracoronary nitroglycerine
  CRT will be performed in the left anterior descending and right coronary arteries. The following measures will be obtained in each of the coronaries first without intracoronary nitrates followed by a dose of 200-500 mcg of intracoronary nitrates and repeat measurements: * Coronary flow reserve (CFR) (normal \> 2.0) * Index of microvascular resistance (IMR) (normal \<25) * Resting ratio of distal coronary pressure to aortic pressure (Pd/Pa) (normal \< 0.91) * Resting and hyperemic (using intravenous adenosine) transit time (Tm) * Resting full-cycle ratio (RFR) * Hyperemic (using intravenous adenosine) fractional flow reserve (FFR) * Resistive reserve ratio (RRR)

Primary Outcome Measure

Assessment of CFR by CRT before and after nitrates [ Time Frame: Intra op ]

Central Contacts

• Bonnie Ostergren
  469-814-4181
  [email protected]

Locations (1)

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