Effect of Daily Mixed Spice Consumption on Memory Function

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT06889961
Status
Recruiting
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Conditions

  • Cognitive Function
  • Memory

Eligibility Criteria

Sex
ALL
Age
50 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Mixed spices — DIETARY_SUPPLEMENT
    Mixed spices 4.00 g capsules of spice mixture contain 1.0 g (25%) turmeric, 1.5 g (37.5%) cinnamon, 0.5 g (12.5%) oregano, 0.5 g (12.5%) black pepper, 0.3 g (7.5%) sage and 0.2 (5%) thyme
  • Placebo — OTHER
    4.00 g maltodextrin capsules

Study Details

The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function. Recent research has indicated that various spices may hold the key to enhancing brain health and combating the effects of aging on cognitive abilities. The hypothesis is that a mixture of spices, acknowledged for their reported memory protection potential, may yield a more potent beneficial effect on memory function than a single spice. The spice mixture will be used at culinary dose, and therefore side effects are anticipated. In this study, the effects of spice mixture will be evaluated, as well as their anti-oxidant, and anti-inflammatory properties. The proposed pilot study will include 50 adults (ages 50-80), exhibiting typical age-related mild cognitive decline, excluding dementia or major neurocognitive disorders. They will be randomized 1:1 assigned into a daily intake of either 4.00 g spice mixture capsules or 4.00 g maltodextrin capsules over 3 months, and explore the sustainable effect over 3 additional months. The changes in symptoms of cognition, fatigue, and mood symptoms of the spice group vs. placebo group will be compared. The outcome of the investigation of the effects of mixed spice consumption will provide important novel information on dietary recommendation of spice to preserve cognitive function in aging population.

Key Dates

Start date
Feb 21, 2025
Status verified
Mar 2025
Primary completion
Feb 21, 2027
Completion
Feb 21, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Mixed spices
  • Placebo Comparator: Placebo

Primary Outcome Measure

Memory [ Time Frame: 6 month ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA Center for Human NutritionLos AngelesCalifornia90024
Hila Zelicha
[email protected]
+1-310-206-8292

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By research site
UCLA Center for Human Nutrition· Los Angeles, CA

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