Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults

Part of paid clinical trials in Flagstaff, Arizona.

Sponsor
Northern Arizona University
Study ID
NCT06872762
Status
Recruiting
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Conditions

  • Control Condition
  • Exercise
  • Heat Strain

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — BEHAVIORAL
    Exercise for 90 minutes (cycling) while minimizing thermal strain
  • Heat strain — BEHAVIORAL
    Exercise for 90 minutes (cycling) while maximizing thermal strain

Study Details

Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy. More and more research is showing that regular environmental stress, for example heat and hypoxia, can further improve physical health. Astronauts aboard the international space station (ISS) exercise for 1-2 hours every day to avoid physical deconditioning that would otherwise cause them to age rapidly in space. Although physical exercise is very effective in remedying this deconditioning, today's astronauts still have physiological changes that indicate accelerated aging. This is a cause for concern given NASA's priority to travel to mars within the next decade; a mission that will require at least double the duration in space for our astronauts. The investigators think that the complete absence of environmental stress, i.e., heat, may be contributing to the accelerated aging that occurs during spaceflight. Our study will assess the health effects of adding heat stress to exercise that could be performed in space by astronauts. The goal is to inform best practice for astronauts to avoid physical deconditioning during long-duration spaceflight. This information will also be relevant to life on earth as spaceflight is a model of inactivity here on earth. Therefore, the potential benefits of adding heat stress will likely translate to life in space and on earth.

Key Dates

Start date
Mar 1, 2025
Status verified
Feb 2025
Primary completion
Dec 31, 2025
Completion
May 21, 2026

Study Design

Enrollment
15 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Exercise
    Participants exercise for 90 minutes trying to remain cool with fans and limited clothing.
  • Experimental: Heat strain
    Participants exercise for 90 minutes wearing winter and rain clothes to develop heat strain.
  • Placebo Comparator: Control
    Resting control for 90 minutes. Not allowed to exercise.

Primary Outcome Measure

Glucose tolerance [ Time Frame: 2 hours after intervention complete ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Northern Arizona UniversityFlagstaffArizona86011
TRAVIS GIBBONS, PhD
[email protected]
928-523-4002

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Northern Arizona University· Flagstaff, AZ

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