Exploring Water-free Sodium Storage

Conditions

• Peritoneal Dialysis, Heart Failure

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• 5% Dextrose/Water — DRUG
  Patients will be randomized to undergo up to two-hour dwell with 5% dextrose in sterile water for 5 days
• 1.5% standard PD fluid — DRUG
  Patients will be randomized to undergo up to two-hour dwell with 1.5% standard PD fluid for 5 days

Study Details

The overarching goal of this proposal is to definitively establish if acute water free Na storage and release occurs, if the amount stored/released is of a quantity that is physiologically relevant, and if the location is intracellular vs. extracellular.

Key Dates

Start date

Oct 3, 2025

Status verified

May 2026

Primary completion

Jun 30, 2028

Completion

Jun 30, 2028

Study Design

Enrollment

10 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: 5% dextrose peritoneal dialysis, 2-hour dwell
  Individuals will receive up to 2 liters of 5% dextrose for peritoneal dialysis during up to a 2-hour dwell for 5 days
• Active Comparator: 1.5% dextrose peritoneal dialysis, 2-hour dwell
  Individuals will receive up to 2 liters of 1.5% dextrose for peritoneal dialysis during up to a 2-hour dwell for 5 days

Primary Outcome Measure

Water free Na removal over the 5-day intervention [ Time Frame: Daily for 5 days ]

Central Contacts

• Veena Rao, PhD
  2037857917
  [email protected]

Locations (1)

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