4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
4D Molecular Therapeutics
Study ID
NCT06864988
Phase
PHASE3
Status
Active Not Recruiting

Conditions

  • Macular Neovascularization Secondary to Age-Related Macular Degeneration

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • 4D-150 IVT (3E10 vg/eye) — BIOLOGICAL
    If randomized to the 4D-150 treatment arm, 4D-150 will be administered at the assigned dose level as a single dose IVT injection on Day 1
  • EYLEA® (aflibercept) Injection 2 mg (0.05mL) — BIOLOGICAL
    Eylea (aflibercept) will be administered at applicable visits

Study Details

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration

Key Dates

Start date
Mar 3, 2025
Status verified
May 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
480 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: 4D-150 IVT (3E10 vg/eye)
  • Active Comparator: Aflibercept (AFLB) 2 mg IVT

Primary Outcome Measure

Mean change from baseline in BCVA ETDRS letter score at Week 52 [ Time Frame: 52 Weeks ]

Locations (91)

FacilityCityStateZIPSite coordinators
Barnet Dulaney Perkins Eye CenterPhoenixArizona85016-
Retinal Research Institute, LLCScottsdaleArizona85254-
Retina Partners of Northwest ArkansasSpringdaleArkansas72764-
California Retina ConsultantsBakersfieldCalifornia93309-
Retina Vitreous Associates Medical GroupBeverly HillsCalifornia90211-
The Retina PartnersEncinoCalifornia91436-
Retina Associates of Southern CaliforniaHuntington BeachCalifornia92647-
Northern California Retina Vitreous AssociatesMountain ViewCalifornia94040-
Retina Consultants of San DiegoPowayCalifornia92064-
Kaiser Permanente-Riverside Medical CenterRiversideCalifornia92505-
Retinal Consultants Medical Group IncSacramentoCalifornia95825-
Retinal Consultants Medical Group IncSacramentoCalifornia95840-
Orange County Retina Medical GroupSanta AnaCalifornia92705-
California Retina Consultants - Santa BarbaraSanta BarbaraCalifornia93103-
Bay Area Retina AssociatesWalnut CreekCalifornia94598-
University of Colorado, DenverAuroraColorado80045-
Retina Consultants of Southern ColoradoColorado SpringsColorado80909-
RSC Research, LLCDenverColorado80210-
Connecticut Eye ConsultantsDanburyConnecticut06810-
Retina Group of FloridaFort LauderdaleFlorida33308-
Vitreo Retinal AssociatesGainesvilleFlorida34481-
Florida Retina Institute - JacksonvilleJacksonvilleFlorida32216-
Florida Retina ConsultantsLakelandFlorida33805-
Florida Retina InstituteOrlandoFlorida32806-
Retina Specialty InstitutePensacolaFlorida32503-
Retina Associates of SarasotaSarasotaFlorida34232-
Retina Vitreous Associates of FloridaSt. PetersburgFlorida33711-
East Florida Eye InstituteStuartFlorida34994-
Southeast Retina CenterAugustaGeorgia30909-
Georgia Retina PCMariettaGeorgia30060-
Retina Consultants of Hawaii‘AieaHawaii96701-
University of ChicagoChicagoIllinois60637-
Retina Associates - ElmhurstElmhurstIllinois60126-
University Retina and Macula Associates, PCLemontIllinois60439-
Illinois Retina AssociatesOak ParkIllinois60304-
Springfield ClinicSpringfieldIllinois62703-
Midwest Eye InstituteCarmelIndiana46290-
Retina Associates of KentuckyLexingtonKentucky40509-
Haik Humble Eye CenterWest MonroeLouisiana71291-
Maine Eye CenterPortlandMaine04101-
Retina Group of Washington, Chevy ChaseChevy ChaseMaryland20815-
Cumberland Valley Retina Consultants PCHagerstownMaryland21740-
Mid Atlantic Retina Specialists - HagerstownHagerstownMaryland21740-
MD Medical ResearchWaldorfMaryland20745-
New England Retina ConsultantsSpringfieldMassachusetts01107-
Mississippi Retina AssociatesMadisonMississippi39110-
Deep Blue Retina Clinical ResearchSouthavenMississippi38671-
The Retina InstituteSt LouisMissouri63128-
Sierra Eye AssociatesRenoNevada89502-
Envision Ocular, LLCBloomfieldNew Jersey07003-
NJ RetinaEdisonNew Jersey08820-
NJ RetinaTeaneckNew Jersey07666-
Eye Associates of New Mexico Vision Research CenterAlbuquerqueNew Mexico87109-
Retina-Vitreous Surgeons of Central New YorkLiverpoolNew York13088-
Vitreous Retina Macula Consultants of New YorkNew YorkNew York10022-
Retina Associates of Western New YorkRochesterNew York14620-
Western Carolina Retinal Associate PAAshevilleNorth Carolina28803-
Duke Eye CenterDurhamNorth Carolina27705-
North Carolina (NC) Retina AssociatesWake ForestNorth Carolina27587-
Piedmont Retina Specialists - Winston Salem OfficeWinston-SalemNorth Carolina27157-
Cole Eye InstituteClevelandOhio44195-
Retina Associates of ClevelandClevelandOhio44122-
Retina Associates of ClevelandClevelandOhio44130-
Retina Vitreous CenterEdmondOklahoma73013-
Verum Research, LLCEugeneOregon97401-
EyeHealth Northwest PeterkortPortlandOregon97225-
Mid Atlantic RetinaBethlehemPennsylvania18017-
Erie Retina ResearchEriePennsylvania16507-
The Scheie Eye InstitutePhiladelphiaPennsylvania19104-
Charleston Neuroscience CenterCharlestonSouth Carolina29414-
Charleston Neuroscience InstituteLadsonSouth Carolina29456-
Palmetto Retina CenterWest ColumbiaSouth Carolina29169-
Black Hills Regional Eye InstituteRapid CitySouth Dakota57701-
Southeastern Retina AssociatesKnoxvilleTennessee37763-
Retina Research Institute of TexasAbileneTexas79606-
Texas Retina AssociatesArlingtonTexas76012-
Austin Clinical ResearchAustinTexas78750-
Austin Research Center for RetinaAustinTexas78705-
Austin Retina AssociatesAustinTexas78705-
Retina & Vitreous of Texas, PLLCBellaireTexas77401-
Retina Consultants of HoustonBellaireTexas77401-
Texas Retina CenterHoustonTexas77043-
RCTX - Westover Hills Retina CenterSan AntonioTexas78251-
Retina Associates of South Texas PASan AntonioTexas78240-
Retina Consultants of Texas San AntonioSan AntonioTexas78240-
Retina Consultants of TexasThe WoodlandsTexas77384-
Strategic Clinical Research Group, LLCWillow ParkTexas76087-
Retina Group of Washington, FairfaxFairfaxVirginia22031-
Piedmont Eye CenterLynchburgVirginia24502-
Retina Institute of VirginiaRichmondVirginia23235-
Eye Clinic of WisconsinWausauWisconsin54403-

Find similar trials in Phoenix, AZ

By research site
Barnet Dulaney Perkins Eye Center· Phoenix, AZRetinal Research Institute, LLC· Scottsdale, AZRetina Partners of Northwest Arkansas· Springdale, ARCalifornia Retina Consultants· Bakersfield, CARetina Vitreous Associates Medical Group· Beverly Hills, CAThe Retina Partners· Encino, CA